Cat. No. 3889
Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene
Biological ActivityGLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Beauchamp et al (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 284 9074. PMID: 19189974.
Joo et al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608. PMID: 19859563.
Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455. PMID: 17494766.
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Keywords: GANT 58, supplier, GANT58, GLI1, inhibits, inhibitors, downstream, Hedgehog, signalling, signaling, Gli, antagonists, Hh, Tocris Bioscience, Hedgehog Signaling Inhibitor products
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