(Z)-FeCP-oxindole

Cat. No. 3883

(Z)-FeCP-oxindole C19H15FeNO [1137967-28-2]

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Chemical Name: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one

Biological Activity

Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM. Geometric isomer of (E)-FeCP-oxindole (Cat. No. 3882).

Technical Data

M.Wt:
329.17
Formula:
C19H15FeNO
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Storage:
Store at +4°C
CAS No:
1137967-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600. PMID: 21359402.

Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918.

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Keywords: (Z)-FeCP-oxindole, supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, Tocris Bioscience, VEGFR Inhibitor products

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