Cat. No. 3881
Biological Activitykisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).
Licensing InformationSold under license
(Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920. PMID: 19321788.
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Citations are publications that use Tocris products. Selected citations for Kisspeptin 234 include:
Fayazi et al (2015) The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Am J Physiol Renal Physiol 13 105. PMID: 26384646.
Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Reprod Biol Endocrinol 7 e44344. PMID: 23028524.
Do you know of a great paper that uses Kisspeptin 234 from Tocris? If so please let us know.
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Keywords: Kisspeptin 234, supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Tocris Bioscience, Kisspeptin Receptor Antagonist products
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