Cat. No. 3881
Biological Activitykisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).
Licensing InformationSold under license
(Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920. PMID: 19321788.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Kisspeptin 234 include:
Fayazi et al (2015) The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Am J Physiol Renal Physiol 13 105. PMID: 26384646.
Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Reprod Biol Endocrinol 7 e44344. PMID: 23028524.
Do you know of a great paper that uses Kisspeptin 234 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Kisspeptin 234, supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Tocris Bioscience, Kisspeptin Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Non-peptide apelin receptor agonistBML 111
FPR2 (lipoxin A4 receptor) agonistAmylin (rat)
Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptorsCalcitonin (human)
Endogenous calcitonin receptor agonist; inhibits bone resorptionSpexin
Potent GAL2/3 agonist; exhibits anxiolytic effects in vivoMM 54
Potent apelin receptor antagonistMSG 606
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands