BCTC

Cat. No. 3875

BCTC C20H25ClN4O [393514-24-4]

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Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

Biological Activity

Orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Technical Data

M.Wt:
372.89
Formula:
C20H25ClN4O
Solubility:
Soluble to 100 mM in DMSO and to 40 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
393514-24-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pomonis et al (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain. J.Pharmacol.Exp.Ther. 306 387. PMID: 12721336.

Valenzano et al (2003) N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. J.Pharmacol.Exp.Ther. 306 377. PMID: 12721338.

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Keywords: BCTC, supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, Tocris Bioscience, TRPV Antagonist products

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