Cat. No. 3875
Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-
Biological ActivityOrally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Pomonis et al (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain. J.Pharmacol.Exp.Ther. 306 387. PMID: 12721336.
Valenzano et al (2003) N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. J.Pharmacol.Exp.Ther. 306 377. PMID: 12721338.
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Keywords: BCTC, supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, Tocris Bioscience, TRPV Antagonist products