Cat. No. 3874
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxim
Biological ActivitySelective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808. PMID: 19525962.
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.
Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.
If you know of a relevant reference for BIO-acetoxime please let us know.
Citations are publications that use Tocris products. Selected citations for BIO-acetoxime include:
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417. PMID: 25616418.
Do you know of a great paper that uses BIO-acetoxime from Tocris? If so please let us know.
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Keywords: BIO-acetoxime, supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products
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