BIO-acetoxime

Cat. No. 3874

BIO-acetoxime C18H12BrN3O3 [667463-85-6]

Price and Availability

For BIO-acetoxime pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime

Biological Activity

Selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Data

M.Wt:
398.21
Formula:
C18H12BrN3O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
667463-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808. PMID: 19525962.

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.

Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses BIO-acetoxime from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: BIO-acetoxime, supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, selective, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Updated in 2015, this guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets. Request copy or view PDF today.

divider line

New Products in this Area

MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Akti-1/2

Potent and selective dual Akt1 and 2 inhibitor

VX 680

High affinity and selective Aurora kinase inhibitor

Imatinib mesylate

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

TGX 221

Potent and selective PI 3-kinase β inhibitor

PF 543 hydrochloride

Potent and selective SphK1 inhibitor

JX 06

Potent and selective PDK1/2/3 inhibitor

MRT 68601 hydrochloride

Potent TBK1 inhibitor

Azoramide

Unfolded protein response (UPR) modulator

LCB 03-0110 dihydrochloride

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

CCT 241533 dihydrochloride

Potent Chk2 inhibitor

IRAK1/4 Inhibitor I

IRAK4 and IRAK1 inhibitor

Centrinone

High affinity and selective PLK4 inhibitor

AZD 3147

Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable

Tilfrinib

Potent and selective breast tumor kinase (Brk) inhibitor

Prostratin

PKC activator; also NF-κB activator

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.