Cat. No. 3873

MeBIO C17H12BrN3O2 [667463-95-8]

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Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime

Biological Activity

Control analog of 6-bromoindirubin-3'-oxime (BIO, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Technical Data

Soluble to 10 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400. PMID: 15077192.

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.

Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.

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Keywords: MeBIO, supplier, GSK-3, inhibitors, inhibits, control, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells, aryl, hydrocarbon, receptor, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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