Cat. No. 3871

Etodolac C17H21NO3 [41340-25-4]

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Chemical Name: (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid

Biological Activity

Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Shi et al (2004) Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats. Acta Pharmacol.Sinica 25 996.

Tachibana et al (2003) Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats. Pharmacology 68 96. PMID: 12711837.

Kato et al (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J.Pharm.Pharmacol. 53 1679. PMID: 11804398.

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Keywords: Etodolac, supplier, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, oxygenases, oxidases, nonsteroidal, anti-inflammatory, drug, NSAID, Tocris Bioscience, Cyclooxygenase Inhibitor products

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