Cat. No. 3870
Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-pi
Biological ActivitySelective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Antonini et al (2009) Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 109 744. PMID: 19245662.
Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549. PMID: 18261749.
Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951. PMID: 17328523.
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Citations are publications that use Tocris products. Selected citations for (±)-PPCC oxalate include:
Malik et al (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. J Biol Chem 172 2519. PMID: 25573298.
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Keywords: (±)-PPCC oxalate, supplier, selective, sigma, receptor, agonists, ligand, sigma2, sigma1, Tocris Bioscience, σ1 Receptor Agonist products
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December 3 - 7, 2016
San Francisco, CA,