(±)-PPCC oxalate

Cat. No. 3870

()-PPCC oxalate C24H29NO3.C2H2O4 [932736-91-9]

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Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester

Biological Activity

Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Antonini et al (2009) Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 109 744. PMID: 19245662.

Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549. PMID: 18261749.

Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951. PMID: 17328523.

If you know of a relevant reference for (±)-PPCC oxalate please let us know.

Citations are publications that use Tocris products. Selected citations for (±)-PPCC oxalate include:

Malik et al (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. J Biol Chem 172 2519. PMID: 25573298.

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Keywords: ()-PPCC oxalate, supplier, selective, sigma, receptor, agonists, ligand, sigma2, sigma1, Tocris Bioscience, σ1 Receptor Agonist products

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