TCS 2002

Cat. No. 3869

TCS 2002 C18H14N2O3S [1005201-24-0]

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Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole

Biological Activity

Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270. PMID: 19775160.

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Keywords: TCS 2002, supplier, TCS2002, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3beta, gsk-3b, gsk-3β, inhibitors, inhibits, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitor products

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