Cat. No. 3868
Chemical Name: 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-
Biological ActivityInducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tsai et al (2010) CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 285 5497. PMID: 20007968.
Wang et al (2008) CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol.Cancer.Ther. 7 350. PMID: 18281518.
If you know of a relevant reference for CHM 1 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CHM 1 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: CHM 1, supplier, CHM1, apoptosis, inducer, inhibits, tubulin, polymerization, inhibitors, antitumor, antivascular, cell, cycle, arrest, Tocris Bioscience, Apoptosis Inducing products