Cat. No. 3868
Chemical Name: 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-
Biological ActivityInducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Tsai et al (2010) CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 285 5497. PMID: 20007968.
Wang et al (2008) CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol.Cancer.Ther. 7 350. PMID: 18281518.
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Keywords: CHM 1, supplier, CHM1, apoptosis, inducer, inhibits, tubulin, polymerization, inhibitors, antitumor, antivascular, cell, cycle, arrest, Tocris Bioscience, Apoptosis Inducing products
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