SKF 86466 hydrochloride

Cat. No. 3866

SKF 86466 hydrochloride C11H14ClN.HCl [86129-54-6]

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Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride

Biological Activity

Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Technical Data

M.Wt:
232.15
Formula:
C11H14ClN.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
86129-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884. PMID: 1981137.

Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1. PMID: 2867209.

Hieble et al (1985) Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90.

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