SKF 86466 hydrochloride
Cat. No. 3866
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydr
Biological ActivityPotent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884. PMID: 1981137.
Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1. PMID: 2867209.
Hieble et al (1985) Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SKF 86466 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SKF 86466 hydrochloride, supplier, Selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, antagonist, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, SKF86466, SK&F, 86466, SKF, Tocris Bioscience, Adrenergic α2 Receptor Antagonist products