SKF 86466 hydrochloride
Cat. No. 3866
Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydr
Biological ActivityPotent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884. PMID: 1981137.
Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1. PMID: 2867209.
Hieble et al (1985) Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90.
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