Licarbazepine

Cat. No. 3865

Licarbazepine C15H14N2O2 [29331-92-8]

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Alternative Name: GP 47779

Chemical Name: 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide

Biological Activity

Active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABAA receptor currents.

Technical Data

M.Wt:
254.28
Formula:
C15H14N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
29331-92-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83. PMID: 18717705.

Benes et al (1999) Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 42 2582. PMID: 10411478.

Calabresi et al (1995) Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 990. PMID: 7555963.

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Keywords: Licarbazepine, supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, GP47779, GP, 47779, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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