Oxcarbazepine

Cat. No. 3864

Oxcarbazepine C15H12N2O2 [28721-07-5]

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Chemical Name: 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide

Biological Activity

Anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.

Technical Data

M.Wt:
252.27
Formula:
C15H12N2O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
28721-07-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zheng et al (2009) Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures. Epilepsia 50 83. PMID: 18717705.

Ambrosio et al (2002) Mechanism of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 27 121. PMID: 11926264.

Schmutz et al (1994) Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 35 S47. PMID: 8039471.

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Keywords: Oxcarbazepine, supplier, antiepileptics, anticonvulsants, anticonvulsives, sodium, channels, voltage-gated, Na+, voltage-dependent, inhibitors, inhibits, NaV, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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