Trovafloxacin mesylate

Cat. No. 3863

Trovafloxacin mesylate C20H15F3N4O3.CH3SO3H [147059-75-4]

Price and Availability

For Trovafloxacin mesylate pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CP 99219

Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329. PMID: 24646995.

Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691. PMID: 9124824.

Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615. PMID: 7872757.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Trovafloxacin mesylate from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Trovafloxacin mesylate, supplier, CP99219, antibiotics, antibacterial, antimicrobial, DNA, topoisomerase, IV, gyrase, dna, synthesis, inhibitors, inhibits, Pfizer, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217