Trovafloxacin mesylate

Cat. No. 3863

Trovafloxacin mesylate C20H15F3N4O3.CH3SO3H [147059-75-4]

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Alternative Name: CP 99219

Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
512.46
Formula:
C20H15F3N4O3.CH3SO3H
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
147059-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Poon et al (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507 329. PMID: 24646995.

Gootz et al (1996) Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 40 2691. PMID: 9124824.

Neu and Chin (1994) In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 38 2615. PMID: 7872757.

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Keywords: Trovafloxacin mesylate, supplier, CP99219, antibiotics, antibacterial, antimicrobial, DNA, topoisomerase, IV, gyrase, dna, synthesis, inhibitors, inhibits, Pfizer, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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