UNC 0224

Cat. No. 3861

UNC 0224 C26H43N7O2 [1197196-48-7]

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Chemical Name: 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

Biological Activity

Potent G9a and GLP inhibitor (IC50 values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9.

Technical Data

M.Wt:
485.67
Formula:
C26H43N7O2
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1197196-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Liu et al (2009) Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 52 7950. PMID: 19891491.

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Keywords: UNC 0224, supplier, UNC0224, potent, inhibitors, inhibits, histone, lysine, methyltransferases, htmase, G9a, epigenetics, GLP, Tocris Bioscience, Lysine Methyltransferase Inhibitor products

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