CH 223191

Cat. No. 3858

CH 223191 C19H19N5O [301326-22-7]

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Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

Biological Activity

Potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dubrovska et al (2012) CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. Br.J.Cancer. 107 43. PMID: 22644306.

Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345. PMID: 20688981.

Veldhoen et al (2009) Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of TH17 T cells. J.Exp.Med. 206 43. PMID: 19114668.

Kim et al (2006) Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol.Pharmacol. 69 1871. PMID: 16540597.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CH 223191 include:

D'Amato et al (2015) A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer. Cancer Res 75 4651. PMID: 26363006.

Matino et al (2015) IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII. Br J Pharmacol 125 3766. PMID: 26426076.

Liu et al (2014) Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor. Immunol Cell Biol 92 200. PMID: 24165981.

Do you know of a great paper that uses CH 223191 from Tocris? If so please let us know.

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Keywords: CH 223191, supplier, CH223191, potent, specific, agonists, aryl, hydrocarbon, receptors, AhR, stem, cells, hematopoietic, expansion, Tocris Bioscience, Aryl Hydrocarbon Receptor Antagonist products

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