Cat. No. 3857
Alternative Name: ICRF-187
Chemical Name: 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)
Biological ActivityTopoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Spallarossa et al (2010) Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. J.Pharmacol.Exp.Ther. 332 87. PMID: 19841470.
Lebrecht et al (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 151 771. PMID: 17519947.
Classen et al (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci. 100 10629.
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Citations are publications that use Tocris products. Selected citations for Dexrazoxane hydrochloride include:
Gardner et al (2011) Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells. Breast Cancer Res 13 R53. PMID: 21595939.
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Keywords: Dexrazoxane hydrochloride, supplier, topoisomerase, II, inhibitors, inhibits, DNA, isomerases, ICRF187, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products