Cat. No. 3856
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylph
Biological ActivityRuBi-caged version of serotonin (Cat. No. 3547). Excited by visible wavelengths (450 nm). Has no effect on firing of pyramidal neurons in mice; uncaging with blue light alters firing rate of COM and CPn neurons, which is blocked by MDL 100907 (Cat. No. 4173).
Licensing InformationSold under licence from Columbia University
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cabrera et al (2017) A visible-light-sensitive caged serotonin. ACS Chem.Neurosci. 8 1036. PMID: 28460173.
Zayat et al (2006) Ruthenium(II) bipyridyl complexes as photolabile caging groups for amines. Inorg. Chem. 45 1728. PMID: 16471986.
If you know of a relevant reference for RuBi-5-HT please let us know.
Citations are publications that use Tocris products. Selected citations for RuBi-5-HT include:
Baj et al (2012) Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 1600. PMID: 22318196.
Do you know of a great paper that uses RuBi-5-HT from Tocris? If so please let us know.
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Keywords: RuBi-5-HT, supplier, caged, serotonin, compounds, neurotransmitters, 5-HT, receptors, serotonergic, Tocris Bioscience, Photolysis products
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