Cat. No. 3852
Alternative Name: 2-PCPA
Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Biological ActivityIrreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Li et al (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27 2992. PMID: 19839055.
Schmidt and McCafferty (2007) trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46 4408. PMID: 17367163.
Lee et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 13 563. PMID: 16793513.
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Citations are publications that use Tocris products. Selected citations for Tranylcypromine hydrochloride include:
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653. PMID: 27133794.
Kearns et al (2015) Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods 12 401. PMID: 25775043.
Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell 21 196. PMID: 20956998.
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Keywords: Tranylcypromine hydrochloride, supplier, irreversible, inhibitors, inhibits, monoamine, oxidase, A, B, MAOA, MAOB, lysine-specific, demethylase, 1, LSD1, BCH110, histone, demethylases, demethylation, oxygenases, oxidases, epigenetics, stem, cells, pluripotency, pluripotent, oct4, KDM1A, Tocris Bioscience, Histone Demethylase Inhibitor products
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