Cat. No. 3849

Gatifloxacin C19H22FN3O4 [112811-59-3]

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Alternative Name: AM 1155

Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Biological Activity

Fluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Desbordes et al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853.

Fukuda et al (1998) Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917. PMID: 9687384.

Takei et al (1998) Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678. PMID: 9756776.

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Keywords: Gatifloxacin, supplier, potent, inhibitors, inhibits, DNA, gyrase, topoisomerase, IV, gatifloxacin, AM1155, fluoroquinolone, antibacterial, antibiotics, stem, cells, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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