Cat. No. 3849
Alternative Name: AM 1155
Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-
Biological ActivityFluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Desbordes et al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853.
Fukuda et al (1998) Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917. PMID: 9687384.
Takei et al (1998) Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678. PMID: 9756776.
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Keywords: Gatifloxacin, supplier, potent, inhibitors, inhibits, DNA, gyrase, topoisomerase, IV, gatifloxacin, AM1155, fluoroquinolone, antibacterial, antibiotics, stem, cells, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products