Cat. No. 3848
Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimeth
Biological ActivityNatural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853.
Wang et al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209. PMID: 18692550.
Qian et al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 4 23.
Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1. PMID: 61710.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Sinomenine hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Sinomenine hydrochloride, supplier, morphinan, analogs, anti-inflammatory, antinociceptive, histamine, mu-opioid, m-opioid, μ-opioid, opioids, agonists, stem, cells, Tocris Bioscience, Histaminergic-Related Compound products