Sinomenine hydrochloride

Cat. No. 3848

Sinomenine hydrochloride C19H23NO4.HCl [6080-33-7]

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Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one hydrochloride

Biological Activity

Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.

Technical Data

Soluble to 100 mM in water
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853.

Wang et al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209. PMID: 18692550.

Qian et al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 4 23.

Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1. PMID: 61710.

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Keywords: Sinomenine hydrochloride, supplier, morphinan, analogs, anti-inflammatory, antinociceptive, histamine, mu-opioid, m-opioid, μ-opioid, opioids, agonists, stem, cells, Tocris Bioscience, Histaminergic-Related Compound products

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Histamine Review

Written by I. de Esch & R. Leurs

Histamine Receptors Scientific Review

Our Histamine review gives an overview of the different histamine receptor subtypes, as well as highlighting pharmacological ligands for their study. View PDF today.

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