Cat. No. 3848
Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimeth
Biological ActivityNatural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602. PMID: 18522853.
Wang et al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209. PMID: 18692550.
Qian et al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 4 23.
Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1. PMID: 61710.
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Keywords: Sinomenine hydrochloride, supplier, morphinan, analogs, anti-inflammatory, antinociceptive, histamine, mu-opioid, m-opioid, μ-opioid, opioids, agonists, stem, cells, Tocris Bioscience, Histaminergic-Related Compound products
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