Cyclic Pifithrin-α hydrobromide
Cat. No. 3843
Alternative Name: Pifithrin-β
Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylpheny
Biological ActivityCyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Zuco and Zunino (2008) Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 10 587. PMID: 18516295.
Barchechath et al (2005) Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α. J.Med.Chem. 48 6409. PMID: 16190767.
Pietrancosta et al (2005) Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg.Med.Chem.Lett. 15 1561. PMID: 15745797.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Cyclic Pifithrin-α hydrobromide from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Cyclic Pifithrin-a hydrobromide, supplier, inhibits, inhibitors, p53, apoptosis, Cyclic, Pifithrin-alpha, hydrobromide, Pifithrin-a, Pifithrin-α, Pifithrin-b, Pifithrin-beta, Pifithrin-β, Tocris Bioscience, p53 Inhibitor products
Find multiple products by catalog number
March 18 - 22, 2017
Little Rock, ARK, USA