Cat. No. 3839
Chemical Name: 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyp
Biological ActivityHedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.USA 106 14132. PMID: 19666565.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses HPI 1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: HPI 1, supplier, HPI1, Hedgehog, Hh, signaling, signalling, inhibitors, inhibits, Gli1, Gli2, Sonic, Shh, SmoM2, Tocris Bioscience, Hedgehog Signaling Inhibitor products
Find multiple products by catalog number
New Products in this Area
Activator of STING-dependent signaling3',3'-cGAMP sodium salt
STING agonist2',3'-cGAMP sodium salt
Endogenous high affinity STING agonistc-Di-AMP sodium salt
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
November 12 - 16, 2016
San Diego, CA, USA