CCMI

Cat. No. 3837

CCMI C19H15Cl2N3O2 [917837-54-8]

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Alternative Name: XY 4083

Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide

Biological Activity

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Technical Data

M.Wt:
388.25
Formula:
C19H15Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage:
Store at -20°C
CAS No:
917837-54-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Hu et al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857. PMID: 20050184.

Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. PMID: 17565004.

Ng et al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc.Natl.Acad.Sci. 104 8059.

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Keywords: CCMI, supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, Nicotinic, Receptors, Acetylcholine, XY4083, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products

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