Cat. No. 3837
Alternative Name: XY 4083
Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophe
Biological ActivityPositive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hu et al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857. PMID: 20050184.
Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715. PMID: 17565004.
Ng et al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc.Natl.Acad.Sci. 104 8059.
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Keywords: CCMI, supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, Nicotinic, Receptors, Acetylcholine, XY4083, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products
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