Cat. No. 3831
Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetr
Biological ActivityNovel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119. PMID: 21152046.
Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760. PMID: 17132853.
Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503. PMID: 11877384.
Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360. PMID: 11463859.
If you know of a relevant reference for LG 100754 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses LG 100754 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: LG 100754, supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, receptors, ppar, peroxisome, proliferator, activated, receptors, PPARgamma, PPARg, PPARγ, agonists, sensitizers, Tocris Bioscience, Retinoid X Receptor products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
July 8 - 12, 2017