NF 340

Cat. No. 3830

NF 340 C37H26N4Na4O15S4 [202982-98-7]

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Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt

Biological Activity

P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively).

Technical Data

M.Wt:
986.84
Formula:
C37H26N4Na4O15S4
Solubility:
Soluble to 20 mM in water
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
202982-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J.Pharmacol.Exp.Ther. 332 238. PMID: 19815812.

If you know of a relevant reference for NF 340 please let us know.

Citations are publications that use Tocris products. Selected citations for NF 340 include:

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29. PMID: 24886406.

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Autophagy 9 31. PMID: 22825617.

Do you know of a great paper that uses NF 340 from Tocris? If so please let us know.

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Keywords: NF 340, supplier, P2Y11, purinoceptors, purines, receptors, antagonists, NF340, Tocris Bioscience, Purinergic (P2Y) Receptor Antagonist products

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