UK 78282 hydrochloride
Cat. No. 3829
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4
Biological ActivityBlocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chandy et al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280. PMID: 15120495.
Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269. PMID: 11384714.
Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707. PMID: 10372812.
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