UK 78282 hydrochloride

Cat. No. 3829

UK 78282 hydrochloride C29H35NO2.HCl [136647-02-4]

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Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride

Biological Activity

Blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.

Technical Data

M.Wt:
466.05
Formula:
C29H35NO2.HCl
Solubility:
Soluble to 50 mM in DMSO and to 30 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
136647-02-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chandy et al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280. PMID: 15120495.

Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269. PMID: 11384714.

Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707. PMID: 10372812.

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Keywords: UK 78282 hydrochloride, supplier, Kv1.3, Kv1.4, blocker, voltage-gated, potassium, K+, channels, UK78282, HCl, inhibits, T-cell, activation, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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