Cat. No. 3828

Rufinamide C10H8F2N4O [106308-44-5]

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Alternative Name: CGP 33101

Chemical Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide

Biological Activity

Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

White et al (2008) The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia 49 1213. PMID: 18325020.

Arroyo (2007) Rufinamide. Neurotherapeutics 4 155. PMID: 17199032.

Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273. PMID: 16621450.

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Keywords: Rufinamide, supplier, CGP33101, sodium, channels, voltage-gated, voltage-dependent, NaV, Na+, prolongs, inactivation, anticonvulsant, anticonvulsive, antiepileptic, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel products

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