CD 2314

Cat. No. 3824

CD 2314 C23H24O2S [170355-37-0]

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Chemical Name: 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid

Biological Activity

Potent and selective RARβ receptor agonist (Kd values are 145 and >3760 nM for RARβ and RARα receptors respectively; no binding detected at RARγ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC50 values are 3.0, 5.7 and 8.0 μM respectively).

Technical Data

M.Wt:
364.5
Formula:
C23H24O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
170355-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Zhao (2009) Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Cancer Res. 69 5218. PMID: 19470764.

Sun (2000) Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin.Cancer Res. 6 1563. PMID: 10778990.

Szondy (1998) Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem.J. 3 767. PMID: 9560303.

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Citations are publications that use Tocris products. Selected citations for CD 2314 include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630. PMID: 27600527.

Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626. PMID: 27611191.

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Keywords: CD 2314, supplier, CD2314, Selective, RARβ, RARbeta, agonists, Retinoic, Acid, Receptors, Tocris Bioscience, Retinoic Acid Receptor Agonist products

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