Cat. No. 3823
Chemical Name: 4-[5-[8-(1-Methylethyl)-4-phenyl-2-
Biological ActivityAntagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Somenzi et al (2007) Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 9 e836. PMID: 17786207.
Ren et al (2005) Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 25 10591. PMID: 16287870.
Kikuchi et al (2001) Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 11 1215. PMID: 11354380.
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Citations are publications that use Tocris products. Selected citations for ER 50891 include:
Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. J Reprod Dev 7 950. PMID: 25888236.
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Keywords: ER 50891, supplier, ER50891, raralpha, rara, rarα, receptors, antagonists, retinoids, retinoic, acid, selective, Tocris Bioscience, Retinoic Acid Receptor Antagonist products
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