Cat. No. 3807

Disulfiram C10H20N2S4 [97-77-8]

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Alternative Name: Tetraethylthiuram disulfide

Chemical Name: Bis(diethylthiocarbamyoyl)disulfide

Biological Activity

Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.

Technical Data

Soluble to 20 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Fisher et al (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J.Pharmacol.Exp.Ther. 332 326. PMID: 19820208.

Johnson et al (2009) Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Anal.Biochem. 398 203. PMID: 20018164.

Cho et al (2007) Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J.Biochem.Mol.Biol. 40 1069. PMID: 18047805.

Starling et al (1996) Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram. Biochem.J. 320 101. PMID: 8947473.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Disulfiram include:

Chan et al (2016) HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells. PLoS One 13 1. PMID: 26728316.

Do you know of a great paper that uses Disulfiram from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Disulfiram, supplier, aldehyde, dehydrogenase, inhibitors, inhibits, anti-alcoholism, stimulates, stimulators, reversible, ca2+-atpase, V-atpase, vacuolar, atpase, MMP, matrix, metalloproteinase, metalloprotease, MMP-2, MMP-9, proteinase, protease, Tocris Bioscience, Ca2+-ATPase Activator products

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