Cat. No. 3800
Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-t
Biological ActivitySelective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kim et al (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 114 349. PMID: 10651997.
Meister et al (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 18 1777. PMID: 9673404.
Szondy et al (1997) Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 51 972. PMID: 9187263.
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Citations are publications that use Tocris products. Selected citations for CD 2665 include:
Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630. PMID: 27600527.
Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. Mucosal Immunol 7 950. PMID: 25888236.
Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101. PMID: 23653115.
Simkin et al (2013) Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut. PLoS One 8 e64077. PMID: 23717535.
Kang et al (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Autophagy 4 66. PMID: 20664575.
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Keywords: CD 2665, supplier, CD2665, selective, retinoic, acid, receptors, gamma, beta, RARgamma, RARbeta, RARb, RARg, RARγ, RAR#946;, antagonists, Tocris Bioscience, Retinoic Acid Receptor Antagonist products
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