CD 2665

Cat. No. 3800

CD 2665 C31H34O5 [170355-78-9]

Price and Availability

For CD 2665 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid

Biological Activity

Selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.

Technical Data

M.Wt:
486.6
Formula:
C31H34O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
170355-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Kim et al (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 114 349. PMID: 10651997.

Meister et al (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 18 1777. PMID: 9673404.

Szondy et al (1997) Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 51 972. PMID: 9187263.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CD 2665 include:

Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101. PMID: 23653115.

Simkin et al (2013) Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut. PLoS One 8 e64077. PMID: 23717535.

Do you know of a great paper that uses CD 2665 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CD 2665, supplier, CD2665, selective, retinoic, acid, receptors, gamma, beta, RARgamma, RARbeta, RARb, RARg, RARγ, RAR#946;, antagonists, Tocris Bioscience, Retinoic Acid Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

RXR and RAR Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, an expert in the field. Request copy or view PDF today.

divider line

New Products in this Area

WAY 252623

Potent LXR agonist

SR 9009

Rev-Erbα/β agonist

SR 9238

Potent and selective LXR inverse agonist

IP7e

Potent Nurr1 activator

Bexarotene

Potent and selective RXR agonist

GSK 2033

Potent LXR antagonist

27-Hydroxycholesterol

LXR agonist; also ER partial agonist

DY 268

Potent FXR antagonist

Cytosporone B

High affinity Nur77 agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.