Cat. No. 3798
Alternative Name: DuP-753
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol
Biological ActivitySelective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rhaleb et al (1991) DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 17 480. PMID: 1672862.
Wong et al (1990) Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 255 584. PMID: 2243344.
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 252 719. PMID: 2179531.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Losartan potassium include:
Thieme and Oliveira-Souza (2015) Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor. PLoS One 10 e0122265. PMID: 25793389.
Santhekadur et al (2014) Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling. FEBS Open Bio 4 353. PMID: 24918049.
Fang et al (2013) Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice. Am J Physiol Heart Circ Physiol 304 H816. PMID: 23292716.
Tsai et al (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. EMBO Mol Med 7 e33527. PMID: 22442695.
Leite-Moreira et al (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147 690. PMID: 16415904.
View Related Products by Target
View Related Products by Product Action
Keywords: Losartan potassium, supplier, Selective, non-peptide, angiotensin, II, A-II, AT1, receptors, antagonists, AT-II, DuP753, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Selective Mas receptor (Ang-(1-7) receptor) antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.