Cat. No. 3797
Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazo
Biological ActivityPutative potassium channel activator; thought to act as a K2P2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Gonczi et al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496. PMID: 16432512.
Tertyshnikova et al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250. PMID: 15608074.
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Keywords: BL 1249, supplier, BL1249, potassium, channel, activators, openers, K2p2.1, trek-1, kcnk2, tpkc1, bladder, selective, Tocris Bioscience, Two-P Potassium Channel Activator products
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