BL 1249

Cat. No. 3797

BL 1249 C17H17N5 [18200-13-0]

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Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

Biological Activity

Putative potassium channel activator; thought to act as a K2P2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Technical Data

Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gonczi et al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496. PMID: 16432512.

Tertyshnikova et al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250. PMID: 15608074.

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Keywords: BL 1249, supplier, BL1249, potassium, channel, activators, openers, K2p2.1, trek-1, kcnk2, tpkc1, bladder, selective, Tocris Bioscience, Non-selective / Other Potassium Channel Activator products

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