Cat. No. 3794

iMAC2 C19H20Br2FN3.2HCl [335166-00-2]

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Chemical Name: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dihydrochloride

Biological Activity

Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Technical Data

Soluble to 5 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Peixoto et al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381. PMID: 19691447.

Bombrun et al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365. PMID: 14521400.

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Keywords: iMAC2, supplier, MAC, inhibitor, mitochondrial, apoptosis-induced, channel, inhibitors, inhibits, reduces, apoptosis, bax, Tocris Bioscience, Other Apoptosis products

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