A 1120

Cat. No. 3793

A 1120 C20H19F3N2O3 [1152782-19-8]

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Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Biological Activity

High affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice. J.Nutr. 140 311. PMID: 20032483.

Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673. PMID: 19147488.

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Keywords: A 1120, supplier, A1120, non-retinoid, retinol-binding, proteins, 4, RBP4, ligands, adipokines, Tocris Bioscience, Miscellaneous Compound products

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