Cat. No. 3793
Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)pip
Biological ActivityHigh affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice. J.Nutr. 140 311. PMID: 20032483.
Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673. PMID: 19147488.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A 1120 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: A 1120, supplier, A1120, non-retinoid, retinol-binding, proteins, 4, RBP4, ligands, adipokines, Tocris Bioscience, Miscellaneous Compound products
Find multiple products by catalog number
New Products in this Area
Polyene antibiotic; inhibits formation of pathological isoform of prion proteinChaetoglobosin A
Antibiotic; selective apoptosis inducer of CLL cells
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.