Hemopressin (human, mouse)

Cat. No. 3791

Hemopressin (human, mouse) Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His

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Biological Activity

Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.

Technical Data

M.Wt:
1054.26
Formula:
C50H79N13O12
Sequence:
PVNFKLLSH
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1314035-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA 104 20588.

Blais et al (2005) Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 26 1317. PMID: 16042973.

Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547. PMID: 12500972.

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Citations are publications that use Tocris products.

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Keywords: Hemopressin (human, mouse), supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Tocris Bioscience, CB1 Receptor Antagonist products

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