Cat. No. 3790
Alternative Name: [D-Ala2, D-Leu5]-Enkephalin
Biological ActivityPrototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100. PMID: 19619518.
Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518. PMID: 1673074.
Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67.
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Keywords: DADLE, supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, Tocris Bioscience, δ Opioid Receptor Agonist products
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November 8 - 10, 2017