Cat. No. 3790

DADLE Tyr-D-Ala-Gly-Phe-D-Leu

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Alternative Name: [D-Ala2, D-Leu5]-Enkephalin

Biological Activity

Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data


(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100. PMID: 19619518.

Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518. PMID: 1673074.

Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67.

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Citations are publications that use Tocris products.

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Keywords: DADLE, supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, Tocris Bioscience, δ Opioid Receptor Agonist products

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