Cat. No. 3787

Viomycin C25H43N13O10.2H2SO4 [32988-50-4]

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Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

Biological Activity

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 75 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493. PMID: 17515906.

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1. PMID: 10619838.

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103. PMID: 2843509.

If you know of a relevant reference for Viomycin please let us know.

Citations are publications that use Tocris products. Selected citations for Viomycin include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105. PMID: 25300478.

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Keywords: Viomycin, supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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