Viomycin

Cat. No. 3787

Viomycin C25H43N13O10.2H2SO4 [32988-50-4]

Price and Availability

For Viomycin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

Biological Activity

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
881.85
Formula:
C25H43N13O10.2H2SO4
Solubility:
Soluble to 75 mM in water
Storage:
Store at -20°C
CAS No:
32988-50-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 14 493. PMID: 17515906.

Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1. PMID: 10619838.

Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103. PMID: 2843509.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Viomycin include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One 232 44105. PMID: 25300478.

Do you know of a great paper that uses Viomycin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Viomycin, supplier, Viomycin, disulfate, Pfizer, antibiotics, inhibits, inhibitors, bacterial, DNA, synthesis, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

PCNA I1

PCNA inhibitor

Pladienolide B

mRNA splicing inhibitor; antitumor

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

AACR 2017

AACR Annual Meeting 2017

April 1 - 5, 2017

Washington, D.C., USA

Booth: 1239