Sildenafil citrate

Cat. No. 3784

Sildenafil citrate C22H30N6O4S.C6H8O7 [171599-83-0]

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Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

Biological Activity

Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
666.7
Formula:
C22H30N6O4S.C6H8O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
171599-83-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689. PMID: 16883306.

Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol.Pharmacol. 56 124. PMID: 10385692.

Ballard et al (1998) Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164. PMID: 9598563.

If you know of a relevant reference for Sildenafil citrate please let us know.

Citations are publications that use Tocris products. Selected citations for Sildenafil citrate include:

Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155. PMID: 24015214.

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Keywords: Sildenafil citrate, supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, Pfizer, Tocris Bioscience, Phosphodiesterase Inhibitor products

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