CP 135807

Cat. No. 3783

CP 135807 C19H21N5O2 [151272-90-1]

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Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine

Biological Activity

Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
351.4
Formula:
C19H21N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
151272-90-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hertel et al (1999) The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 1175. PMID: 10462130.

Mansbach et al (1996) CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology 128 313. PMID: 8972551.

Rollema et al (1996) Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J.Neurochem. 67 2204. PMID: 8863532.

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Keywords: CP 135807, supplier, selective, 5-HT, serotonin, 5-HT1D, receptors, agonists, Pfizer, CP135807, Tocris Bioscience, 5-HT1D Receptor Agonist products

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