Atorvastatin hemicalcium salt

Cat. No. 3776

Atorvastatin hemicalcium salt C33H34FN2O5.½Ca [134523-03-8]

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Alternative Name: Lipitor

Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
577.67
Formula:
C33H34FN2O5.½Ca
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
134523-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Turner et al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315.

Santodomingo-Garzon et al (2006) Atorvastatin inhibits inflammatory hypernociception. Br.J.Pharmacol. 149 14. PMID: 16865092.

Vaughan et al (2004) Update on statins: 2003. Circulation 110 886. PMID: 15313959.

Istvan et al (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160. PMID: 11349148.

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Keywords: Atorvastatin hemicalcium salt, supplier, HMG-CoA, reductases, inhibitors, inhibits, cholesterol, biosynthesis, LDL, Pfizer, Tocris Bioscience, HMG-CoA Reductase Inhibitor products

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