Linezolid

Cat. No. 3765

Linezolid C16H20FN3O4 [165800-03-3]

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Alternative Names: PNU 100766, U 100766

Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

Biological Activity

Oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
337.35
Formula:
C16H20FN3O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
165800-03-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Brickner et al (2008) Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J.Med.Chem. 51 1981. PMID: 18338841.

Brickner et al (1996) Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections. J.Med.Chem. 39 673. PMID: 8576909.

Ford et al (1996) In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob.Agents Chemother. 40 1508. PMID: 8726028.

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Keywords: Linezolid, supplier, PNU100766, U100766, antibacterial, antibiotics, gram-positive, bacteria, protein, synthesis, inhibitors, inhibits, Pfizer, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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