Tolterodine L-tartrate

Cat. No. 3761

Tolterodine L-tartrate C22H31NO.C4H6O6 [124937-52-6 ]

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Chemical Name: 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (2R,3R)-2,3-dihydroxybutanedioate

Biological Activity

High affinity muscarinic receptor antagonist (Ki = 3.3 nM). Active at all muscarinic receptor subtypes (M1 - M5); exhibits a greater effect on the bladder than salivary glands in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
475.57
Formula:
C22H31NO.C4H6O6
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
124937-52-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nilvebrant (2001) Clinical experiences with tolterodine. Life Sci. 68 2549. PMID: 11392625.

Nilvebrant et al (1997) Tolterodine - a new bladder-selective antimuscarinic agent. Eur.J.Pharmacol. 327 195. PMID: 9200560.

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Keywords: Tolterodine L-tartrate, supplier, high, affinity, muscarinic, receptors, antagonists, M1, M2, M3, M4, M5, acetylcholine, ACh, Pfizer, Tolterodine, L-tartrate, Tocris Bioscience, Non-selective Muscarinic Antagonist products

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