Exemestane

Cat. No. 3759

Exemestane C20H24O2 [107868-30-4]

Price and Availability

For Exemestane pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: FCE 24304, EXE

Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione

Biological Activity

Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
296.4
Formula:
C20H24O2
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
107868-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829. PMID: 18695261.

Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281. PMID: 17079446.

Goss et al (2004) The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats. Bone 34 384. PMID: 15003786.

di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Exemestane from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Exemestane, supplier, Pfizer, aromatase, inhibitors, inhibits, estrogen, synthesis, CYP19, Cytochrome, P450, FCE24304, Tocris Bioscience, Cytochrome P450 Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

PF 04449613

Potent PDE9 inhibitor; brain penetrant

Eggmanone

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Sign-up for new product e-alerts
divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2017

Epigenetic Regulation of Stem Cell Differentiation

March 1, 2017

Amsterdam, The Netherlands