Dofetilide

Cat. No. 3757

Dofetilide C19H27N3O5S2 [115256-11-6]

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Alternative Names: Tikosyn, UK 68798

Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Biological Activity

Selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
441.56
Formula:
C19H27N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
115256-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Finlayson et al (2001) [3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel. Eur.J.Pharmacol. 412 203. PMID: 11166283.

Carmeliet (1992) Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofetilide. J.Pharmacol.Exp.Ther. 262 809. PMID: 1501123.

Gwilt et al (1991) UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J.Pharmacol.Exp.Ther. 256 318. PMID: 1988662.

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Citations are publications that use Tocris products. Selected citations for Dofetilide include:

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42. PMID: 20926757.

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Keywords: Dofetilide, supplier, UK68798, hERG, K+, potassium, channels, blockers, inhibits, IKR, delayed, rectifier, currents, Kv, voltage-gated, voltage-dependent, Human, Ether-A-Go-Go, Gene, Pfizer, KV11.1, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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