Cat. No. 3751
Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-prop
Biological ActivitySelective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kiyonaka et al (2009) Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc.Natl.Acad.Sci. 106 5400.
If you know of a relevant reference for Pyr3 please let us know.
Citations are publications that use Tocris products. Selected citations for Pyr3 include:
Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. Am J Physiol Regul Integr Comp Physiol 7. PMID: 25873305.
Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. ACS Chem Neurosci 305 R917. PMID: 23948776.
Do you know of a great paper that uses Pyr3 from Tocris? If so please let us know.
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Keywords: Pyr3, supplier, canonical, transient, receptor, potential, TRPC3, channels, inhibitors, inhibits, Tocris Bioscience, TRPC Blocker products