RN 1747

Cat. No. 3745

RN 1747 C17H18ClN3O4S [1024448-59-6]

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Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Biological Activity

Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Technical Data

M.Wt:
395.87
Formula:
C17H18ClN3O4S
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
1024448-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.

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Citations are publications that use Tocris products. Selected citations for RN 1747 include:

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Am J Physiol Renal Physiol 21 4852. PMID: 25944998.

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. World J Gastroenterol 305 F396. PMID: 23720349.

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Keywords: RN 1747, supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, Tocris Bioscience, TRPV Agonist products

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