Asenapine maleate

Cat. No. 3737

Asenapine maleate C17H16ClNO.C4H4O4 [85650-56-2]

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Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

Biological Activity

Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Marston et al (2009) Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 206 699.

Meltzer et al (2009) Asenapine. Nat.Rev.Drug Discov. 8 843. PMID: 19876039.

Shahid et al (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 23 65. PMID: 18308814.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Asenapine maleate include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Do you know of a great paper that uses Asenapine maleate from Tocris? If so please let us know.

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Keywords: Asenapine maleate, supplier, antipsychotics, 5-HT, serotonin, receptors, dopamine, alpha-adrenoceptors, a-adrenoceptors, α-adrenoceptors, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, Tocris Bioscience, Non-selective 5-HT Antagonist products

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