Cat. No. 3737
Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-te
Biological ActivityNovel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Marston et al (2009) Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 206 699.
Meltzer et al (2009) Asenapine. Nat.Rev.Drug Discov. 8 843. PMID: 19876039.
Shahid et al (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 23 65. PMID: 18308814.
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Citations are publications that use Tocris products. Selected citations for Asenapine maleate include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.
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Keywords: Asenapine maleate, supplier, antipsychotics, 5-HT, serotonin, receptors, dopamine, alpha-adrenoceptors, a-adrenoceptors, α-adrenoceptors, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, Tocris Bioscience, Non-selective 5-HT Antagonist products
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