UPF 1069

Cat. No. 3736

UPF 1069 C17H13NO3 [1048371-03-4]

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Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Biological Activity

Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Technical Data

M.Wt:
279.29
Formula:
C17H13NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1048371-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Moroni et al (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol. 157 854. PMID: 19422384.

Pellicciari et al (2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem 3 914.

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Keywords: UPF 1069, supplier, PARP2, poly(ADP-ribose), polymerases, inhibitors, inhibits, UPF1069, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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