Cat. No. 3736
Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydr
Biological ActivitySelective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moroni et al (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol. 157 854. PMID: 19422384.
Pellicciari et al (2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem 3 914.
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Keywords: UPF 1069, supplier, PARP2, poly(ADP-ribose), polymerases, inhibitors, inhibits, UPF1069, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products
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